Article

Selective loss of the GABA <sub>Aα1</sub> subunit from Purkinje cells is sufficient to induce a tremor phenotype

2019-09-19

Abstract excerpt

<h4>Background</h4> Increased circuit level insights into Essential tremor, the most prevalent movement disorder, are needed. Previously, an Essential Tremor-like phenotype was noted in animals with a global knockout of the GABA Aα1 subunit. However, global knockout of the GABA Aα1 subunit has limitations, including potential early mortality and limited circuit level insights into the tremor. <h4>Methods</h4>...

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Literature Corpus work: 3095e67b-f382-598c-9c1b-9f618eea23e7
DOI: 10.1101/773655

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