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Article

Impaired motor function in mice with cell-specific knockout of sodium channel Scn8a (NaV1.6) in cerebellar purkinje neurons and granule cells.

Journal of neurophysiology - 1 Aug 2006

Levin Stephen I, Khaliq Zayd M, Aman Teresa K, Grieco Tina M, Kearney Jennifer A, Raman Indira M, Meisler Miriam H

Abstract excerpt

The Scn8a gene encodes the voltage-gated Na channel alpha subunit Na(V)1.6, which is widely expressed throughout the nervous system. Global null mutations that eliminate Scn8a in all cells result in severe motor dysfunction and premature death, precluding analysis of the physiological role of Na(V)1.6 in different neuronal types. To test the effect of cerebellar Na(V)1.6 on motor coordination in mice, we used the...

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Identifiers

PMID: 16687615
DOI: 10.1152/jn.01193.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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