Architects of infection: A structural overview of SARS-related coronavirus spike glycoproteins

Abstract excerpt

The frequency of zoonotic viral emergence within the Coronaviridae family highlights the critical need to understand the structural features of spike proteins that govern viral entry and host adaptation. Investigating the structural conservation and variation in key regions of the spike protein—those involved in host range, binding affinity, viral entry, and immune evasion—is essential for predicting the...