Article
[Pre-mRNA splicing: when the spliceosome loses ground].
Medecine sciences : M/S - 1 Dec 2016
Dujardin Gwendal, Daguenet Élisabeth, Bernard Delphine G, Flodrops Marion, Durand Stéphanie, Chauveau Aurélie, El Khoury Flaria, Le Jossic-Corcos Catherine, Corcos Laurent
Abstract excerpt
Pre-mRNA splicing is an obligatory step required to assemble the vast majority of mRNAs in eukaryotes. In humans, each gene gives rise to at least two transcripts, with an average 6-8 spliced transcripts per gene. Pre-mRNA splicing is not unequivocal. Variations may occur, such that splicing can become alternative, thereby participating in increasing protein variability and restricting the gap that exists between...
Topics
- Alternative Splicing
- Animals
- Disease Progression
- Humans
- Mutation
- Neoplasms
- RNA Precursors
- RNA Splicing
- RNA, Messenger
- Spliceosomes