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Article

A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis

1 Jan 2010

Abstract excerpt

Transforming growth factor beta (TGFbeta) is a growth factor with many faces. In our osteoarthritis (OA) research we have found that TGFbeta can be protective as well as deleterious for articular cartilage. We postulate that the dual effects of TGFbeta on chondrocytes can be explained by the fact that TGFbeta can signal via different receptors and related Smad signaling routes. On chondrocytes, TGFbeta not only...

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PMID: 20156325
DOI: 10.1186/ar2896

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