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Article

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration.

Cell reports - 23 Mar 2021

Russ Kaspar, Teku Gabriel, Bousset Luc, Redeker Virginie, Piel Sara, Savchenko Ekaterina, Pomeshchik Yuriy, Savistchenko Jimmy, Stummann Tina C, Azevedo Carla, Collin Anna, Goldwurm Stefano, Fog Karina, Elmer Eskil, Vihinen Mauno, Melki Ronald, Roybon Laurent

Abstract excerpt

Here, we examine the cellular changes triggered by tumor necrosis factor alpha (TNF-α) and different alpha-synuclein (αSYN) species in astrocytes derived from induced pluripotent stem cells. Human astrocytes treated with TNF-α display a strong reactive pro-inflammatory phenotype with upregulation of pro-inflammatory gene networks, activation of the nuclear factor κB (NF-κB) pathway, and release of...

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PMID: 33761362
DOI: 10.1016/j.celrep.2021.108895

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