Article

Synovial lining–expressed mechanosensor PIEZO1 drives inflammation-permissive macrophage phenotypes and joint inflammation

2026-01-13

Abstract excerpt

Synovial tissue–resident macrophages regulate immune homeostasis within the joint, but can adopt an inflammation-permissive phenotype that promotes immune cell infiltration in rheumatoid arthritis (RA). Understanding the factors that drive this phenotypic switch may help prevent the localisation of inflammation in the joints of individuals at-risk of RA. We identified the mechanosensitive ion channel PIEZO1 as a p...

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Literature Corpus work: 9107370b-ddd2-5dbe-9aef-58c99b061bb0
DOI: 10.64898/2026.01.12.699005

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