Article

Mortality Risk-Stratified Septic Serum Depresses Contractility and Mitochondrial Function in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

2025-12-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Sepsis-associated myocardial dysfunction (SAMD) is common in children with septic shock, is independently associated with mortality, and has no disease-modifying treatments. Differences in murine cardiomyocyte biology and repeated failures to translate discoveries into novel therapies for septic shock underscore a key translational need for human-relevant disease modeling. W...

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Literature Corpus work: 30444e31-ec5e-57dc-ac78-5d49619d09bc
DOI: 10.64898/2025.12.21.695853

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