Article

Lipid Nanoparticle Delivery of Mesenchymal Stromal Cell-Derived microRNA 187-3p as a First-in-Class Therapy for Myocardial Dysfunction in Sepsis

2025-09-14

Abstract excerpt

<h4>Background</h4> Sepsis-induced myocardial dysfunction is a common and critical complication of sepsis. Extracellular vesicles (EVs) from clonally expanded immortalized mesenchymal stromal cells (ciMSCs) contain microRNAs that may be exploited as therapy. <h4>Methods</h4> In mouse models of septic cardiomyopathy induced by caecum ligation and puncture, cardiac function was determined by invasive and echocardi...

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Literature Corpus work: fe616055-044c-5efd-b337-de8ce693b58e
DOI: 10.1101/2025.09.09.674991

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