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Article

Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock

19 Nov 2014

Abstract excerpt

INTRODUCTION: Increasing evidence supports a role for mitochondrial dysfunction in organ injury and immune dysregulation in sepsis. Although differential expression of mitochondrial genes in blood cells has been reported for several diseases in which bioenergetic failure is a postulated mechanism, there are no data about the blood cell mitochondrial transcriptome in pediatric sepsis. METHODS: We conducted a...

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PMID: 25410281
DOI: 10.1186/s13054-014-0623-9

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