Article

Derivation, validation, and clinical relevance of a pediatric sepsis phenotype with persistent hypoxemia and shock

2022-12-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Untangling the heterogeneity of sepsis in children and identifying clinically relevant phenotypes could lead to the development of enrichment strategies and targeted therapies. In this study, our aim was to analyze the organ dysfunction-based trajectories of children with sepsis-associated multiple organ dysfunction syndrome (MODS) to identify and characterize reproducible and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 08315545-fda8-5063-a85a-e476c1d85c10
DOI: 10.1101/2022.12.23.22283912

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Derivation, validation, and clinical relevance of a pediatric sepsis phenotype with persistent hypoxemia and shockDOI 10.1101/2022.12.23.22283912Read

Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock.Semantic proximity Read

External validation and biomarker assessment of a high-risk, data-driven pediatric sepsis phenotype characterized by persistent hypoxemia, encephalopathy, and shock.Semantic proximity Read

Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock.Semantic proximity Read

Derivation and Validation of Novel Phenotypes of Multiple Organ Dysfunction Syndrome in Critically Ill Children.Semantic proximity Read

Derivation, validation, and transcriptomic assessment of pediatric septic shock phenotypes identified through latent profile analyses: Results from a prospective multi-center observational cohortSemantic proximity Read

Machine learning driven identification of gene-expression signatures correlated with multiple organ dysfunction trajectories and complex sub-endotypes of pediatric septic shockSemantic proximity Read

Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials.Semantic proximity Read

EMERGENCE OF A TECHNOLOGY-DEPENDENT PHENOTYPE OF PEDIATRIC SEPSIS IN A LARGE CHILDREN'S HOSPITAL.Semantic proximity Read

Microvascular phenotypes in pediatric sepsis identified by machine learning: prognostic implications for organ dysfunction and mortality.Semantic proximity Read

Derivation of four computable 24-hour pediatric sepsis phenotypes to facilitate personalized enrollment in early precise anti-inflammatory clinical trialsSemantic proximity Read

Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes.Semantic proximity Read

Identifying a Refractory Shock Phenotype in Pediatric Sepsis Using a Vasoactive-Adjusted Shock Index.Semantic proximity Read