Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock.

doi:10.1097/PCC.0000000000003292

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies - 1 Oct 2023

Sanchez-Pinto L Nelson, Bennett Tellen D, Stroup Emily K, Luo Yuan, Atreya Mihir, Bubeck Wardenburg Juliane, Chong Grace, Geva Alon, Faustino E Vincent S, Farris Reid W, Hall Mark W, Rogerson Colin, Shah Sareen S, Weiss Scott L, Khemani Robinder G

Abstract excerpt

OBJECTIVES: Untangling the heterogeneity of sepsis in children and identifying clinically relevant phenotypes could lead to the development of targeted therapies. Our aim was to analyze the organ dysfunction trajectories of children with sepsis-associated multiple organ dysfunction syndrome (MODS) to identify reproducible and clinically relevant sepsis phenotypes and determine if they are associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child

Share to Clinical Relevance

Share to Hypoxia

Share to Multiple Organ Failure

Share to Reproducibility of Results

Share to Sepsis

Share to Shock, Septic

Source

Open in PubMed Open full text

Identifiers

PMID: 37272946
DOI: 10.1097/PCC.0000000000003292
PMCID: PMC10540758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock.PMID 37272946Read ↗

Derivation, validation, and clinical relevance of a pediatric sepsis phenotype with persistent hypoxemia and shockSemantic proximity Read ↗

Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock.Semantic proximity Read ↗

External validation and biomarker assessment of a high-risk, data-driven pediatric sepsis phenotype characterized by persistent hypoxemia, encephalopathy, and shock.Semantic proximity Read ↗

Derivation and Validation of Novel Phenotypes of Multiple Organ Dysfunction Syndrome in Critically Ill Children.Semantic proximity Read ↗

Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials.Semantic proximity Read ↗

EMERGENCE OF A TECHNOLOGY-DEPENDENT PHENOTYPE OF PEDIATRIC SEPSIS IN A LARGE CHILDREN'S HOSPITAL.Semantic proximity Read ↗

Microvascular phenotypes in pediatric sepsis identified by machine learning: prognostic implications for organ dysfunction and mortality.Semantic proximity Read ↗

Derivation, validation, and transcriptomic assessment of pediatric septic shock phenotypes identified through latent profile analyses: Results from a prospective multi-center observational cohortSemantic proximity Read ↗

Machine learning driven identification of gene-expression signatures correlated with multiple organ dysfunction trajectories and complex sub-endotypes of pediatric septic shockSemantic proximity Read ↗

Derivation of four computable 24-hour pediatric sepsis phenotypes to facilitate personalized enrollment in early precise anti-inflammatory clinical trialsSemantic proximity Read ↗

Pediatric Sepsis Diagnosis, Management, and Sub-phenotypes.Semantic proximity Read ↗

Identifying a Refractory Shock Phenotype in Pediatric Sepsis Using a Vasoactive-Adjusted Shock Index.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.