Article

PTPRN hypermethylation-driven transcriptional repression defines a conserved regulatory axis in early- and adult-onset schizophrenia

2026-07-08

Abstract excerpt

<title>Abstract</title> <p> Schizophrenia is a complex polygenic neuropsychiatric disorder with over 50% of its heritability remaining unexplained. Epigenetic mechanisms such as DNA methylation represent an interface for gene-environment interactions that shape transcriptional programs underpinning neurodevelopment and brain function. However, it remains unclear whether patient‑derived cellular models capture ep...

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Literature Corpus work: 3036f256-e646-5b37-bdc2-400de14ad44a
DOI: 10.21203/rs.3.rs-9956001/v1

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