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Article

Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation.

Cell reports - 25 Feb 2025

Shen Ting, Yu Jing, Xie Bin, Huang Cuiping, Cui Jingjie, Liu Kefu, Liu Chunyu, Chen Chao

Abstract excerpt

Genome-wide association studies (GWASs) have identified numerous genomic loci linked to schizophrenia (SCZ), while their pathogenic mechanisms largely remain unclear. This study demonstrated protein arginine methyltransferase 7 (PRMT7) as a key target of SCZ risk SNPs with allele-specific enhancer activity at 16q22.1. Downregulating PRMT7 in neural progenitor cells (NPCs) decreased proliferation, increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39921858
DOI: 10.1016/j.celrep.2025.115279

Genes

PRMT7
CDKN2A
SYP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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