Article

CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion, and therapeutic resistance

2022-07-06

Abstract excerpt

Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults and remains incurable. The mitochondrial coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (CHCHD2) is demonstrated to mediate mitochondrial respiration, nuclear gene expression, and cell migration, but evidence of this in GBM is lacking. We hypothesized that CHCHD2 would serve a functional role in U87 GBM cells express...

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Literature Corpus work: 30347b1f-ea4c-53d3-afdd-356e7a8b6d92
DOI: 10.1101/2022.07.05.498855

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