Structural remodeling of tumor microtubes in IDH1 mutation shapes microRNA transfer in glioma.

Abstract excerpt

Tumor microtubes (TMs) are actin- and tubulin-based protrusions interconnecting glioma cells into multicellular networks linked to tumor aggressiveness, but the molecular signals exchanged through them and the impact of IDH1 mutation on TM function remain poorly defined. Using isogenic U87 glioma cells expressing wild-type IDH1 (U87IDH-WT) or the IDH1-R132H mutant (U87IDH-R132H), we combined quantitative...

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