Article

MAT2a and AHCY inhibition disrupts antioxidant metabolism and reduces glioblastoma cell survival

2024-11-24

Abstract excerpt

Glioblastoma (GBM) is a highly aggressive primary malignant adult brain tumor that inevitably recurs with a fatal prognosis. This is due in part to metabolic reprogramming that allows tumors to evade treatment. We therefore must uncover the pathways mediating these adaptations to develop novel and effective treatments. We searched for genes that are essential in GBM cells as measured by a whole-genome pan-cancer C...

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Identifiers and source

Literature Corpus work: 47402cd5-a6de-5381-8389-374fe06c2970
DOI: 10.1101/2024.11.23.624981

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