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Stem cell–derived CAR T cells traffic to HIV reservoirs in macaques

10 Jan 2021

Abstract excerpt

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) with CCR5- donor cells is the only treatment known to cure HIV-1 in patients with underlying malignancy. This is likely due to a donor cell-mediated graft-versus-host effect targeting HIV reservoirs. Allo-HSCT would not be an acceptable therapy for most people living with HIV due to the transplant-related side effects. Chimeric antigen receptor (CAR)...

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PMID: 33427210
DOI: 10.1172/jci.insight.141502

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