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Article

Robust CAR-T memory formation and function via hematopoietic stem cell delivery

1 Apr 2021

Abstract excerpt

Due to the durability and persistence of reservoirs of HIV-1-infected cells, combination antiretroviral therapy (ART) is insufficient in eradicating infection. Achieving HIV-1 cure or sustained remission without ART treatment will require the enhanced and persistent effective antiviral immune responses. Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy and show promise in treating...

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PMID: 33793675
DOI: 10.1371/journal.ppat.1009404

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