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Article

Broadly neutralizing antibody–derived CAR T cells reduce viral reservoir in individuals infected with HIV-1

10 Aug 2021

Abstract excerpt

BACKGROUNDChimeric antigen receptor (CAR) T cells have emerged as an approach to treat malignant tumors. This strategy has also been proposed for the treatment of HIV-1 infection. We have developed a broadly neutralizing antibody-derived (bNAb-derived) CAR T cell therapy that can exert specific cytotoxic activity against HIV-1-infected cells.METHODSWe conducted an open-label trial of the safety, side-effect...

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PMID: 34375315
DOI: 10.1172/jci150211

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