Article

Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense

2020-09-08

Abstract excerpt

<title>Abstract</title> Resistance to African trypanosomes in humans relies on targeting of a trypanosome lytic factor 1 (TLF1) to trypanosome haptoglobin-hemoglobin receptor (HpHbR). While TLF1 avoidance by the inactivation of the HpHbR contributes to Trypanosoma brucei gambiense human infectivity, the evolutionary trade-off of this adaptation is unknown. Both T. b. gambiense with inactive HpHbR, as well as a...

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Literature Corpus work: 36361e11-f4b3-5f64-bf48-f44f059a0aef
DOI: 10.21203/rs.3.rs-49796/v1

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