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Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in <i>Trypanosoma brucei gambiense</i>

2022-05-13

Abstract excerpt

<h4>ABSTRACT</h4> Resistance to African trypanosomes in humans relies in part on the high affinity targeting of a trypanosome lytic factor 1 (TLF1) to a trypanosome haptoglobin-hemoglobin receptor (HpHbR). While TLF1 avoidance by the inactivation of HpHbR contributes to Trypanosoma brucei gambiense human infectivity, the evolutionary trade-off of this adaptation is unknown, as the physiological function of the r...

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Literature Corpus work
0e8b18cc-969d-5409-99b8-1e6483159a7e
DOI
10.1101/2022.05.12.491725
Open publication

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