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Article

Genetic overlap between depression and C-reactive protein levels: Evidence from a cross-trait analysis.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Nov 2026

Rodríguez-Romero Manuel Donato, Carabí-Gassol Pau, Cabana-Domínguez Judit, Llonga Natalia, Zubizarreta-Arruti Uxue, Graell Marta, Macias-Chimborazo Valeria, Ramos-Quiroga Josep Antoni, Arteaga-Henriquez Gara, Ribasés Marta, Alemany Silvia, Soler Artigas María

Abstract excerpt

Inflammation and depression have been consistently associated, with elevated C-reactive protein (CRP) levels observed in a significant subset of affected individuals. However, the genetic mechanisms underlying this association remain poorly understood. We integrated results from large-scale genome-wide association studies (GWAS) of depression and CRP levels in a cross-trait analysis specifically focusing on...

Read the complete abstract on PubMed

Topics

C-Reactive Protein
Humans
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Body Mass Index

Depression

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 42320223
DOI: 10.1016/j.euroneuro.2026.112901

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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