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Article

Uncovering plasma protein biomarkers linked to depression: A differential abundance analysis and Mendelian randomization using large-scale data.

Journal of affective disorders - 15 Apr 2026

Abebe Endeshaw, Mulugeta Anwar, Madakkattel Iqbal, Stacey David, Hyppönen Elina

Abstract excerpt

BACKGROUND: Plasma proteins are potential biomarkers and drug targets that offer insights into the biological underpinnings of depression; yet, evidence linking them to depression is scarce. METHODS: To identify depression-linked proteins, we conducted differential protein abundance analysis (DPAA) on 2920 plasma proteins among 48,378 UK Biobank participants. Among DPAA-identified proteins, we conducted network...

Topics

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Biomarkers
Blood Proteins
Depression
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 41500316
DOI: 10.1016/j.jad.2025.121134

Genes

ADAMTS8
TNFRSF10B
BTN3A2
CNTN5
CXADR
IGFBP4
LGALS4
PRSS8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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