Back to search

Article

Tetrahydrocannabinol derivative ameliorates 5-FU mediated DNA damage propensity coupled with Vimentin suppression leading to autophagy induction

2023-09-19

Abstract excerpt

<title>Abstract</title> <p>Anastasis cascade including induction of Epithelial to Mesenchymal Transition ( EMT), DNA repair, and stimulation of pro-survival mediators collectively exaggerate therapy resistance in cancer prognosis. The extensive implications of DNA-damaging agents are clinically proven futile for the rapid development of disease recurrence during treatment regime. In order to tackle this catastrop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2ff49c85-c212-514e-9ab8-adf4d1d421b8
DOI
10.21203/rs.3.rs-3266520/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Tetrahydrocannabinol derivative ameliorates 5-FU mediated DNA damage propensity coupled with Vimentin suppression leading to autophagy inductionDOI 10.21203/rs.3.rs-3266520/v1
A Tale of Two Cell Lines: Characterization of differential efficacy of small molecule drugs cediranib and NU-7441 on primary vs. metastatic colorectal cancerSemantic proximity
Astragali Radix - Curcumae Rhizoma synergistically potentiates 5-fluorouracil antitumor efficacy in colorectal cancer by disrupt DNA repair–cell cycle coordinationSemantic proximity
Chiaurinib Selectively Inhibits Colorectal Cancer with KRAS Wild-Type by Modulation of ROS through Activating the p53 Signaling PathwaySemantic proximity
P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathwaySemantic proximity
Radiation-induced DNA damage response and resistance in colorectal cancer stem-like cellsSemantic proximity
The rational modulation of autophagy sensitizes colorectal cancer cells to 5-fluouracil and OxaliplatinSemantic proximity
Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal CancerSemantic proximity
The dicarbonyl electrophile scavenger 2-hydroxybenzylamine (2-HOBA) prevents colorectal carcinogenesis and reduces tumor growthSemantic proximity
Three-dimensionally Specific Inhibition of DNA Repair-Related Genes by Activated KRAS in Colon Crypt ModelSemantic proximity
Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin.Semantic proximity
MBD4frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cellsSemantic proximity
UHMK1 Dependent Phosphorylation of Cajal Body Protein Coilin Altered 5-FU Sensitivity in Colon Cancer CellsSemantic proximity
Select a neighboring publication to make it the new centre.