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Chiaurinib Selectively Inhibits Colorectal Cancer with KRAS Wild-Type by Modulation of ROS through Activating the p53 Signaling Pathway

2020-07-23

Abstract excerpt

<h4>Background: </h4> Colorectal cancer (CRC) is one of the top three most deadly cancers despite using chemotherapy based on oxaliplatin or irinotecan combined with targeted therapy. Chiaurinib has recently been identified to be a promising anticancer candidate with impressive efficacy and safety. However, the role and molecular mechanisms of Chiaurinib in the treatment of CRC remain to be elucidated. <h4>Methods...

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Literature Corpus work
62d3657a-4981-59d8-961f-f478bd45fbc8
DOI
10.21203/rs.3.rs-46779/v1
Open publication

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