Article
Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin.
Neoplasia (New York, N.Y.) - 1 Apr 2017
Wiegering Armin, Matthes Niels, Mühling Bettina, Koospal Monika, Quenzer Anne, Peter Stephanie, Germer Christoph-Thomas, Linnebacher Michael, Otto Christoph
Abstract excerpt
Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently dysregulated intracellular signaling pathways, including p53 signaling. The mainstay of chemotherapy treatment of CRC is 5-fluorouracil (5FU) and oxaliplatin. The two anticancer drugs mediate their therapeutic effect via DNA damage-triggered signaling. The small molecule reactivating p53 and inducing tumor apoptosis...
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