Article

Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer

2021-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Patients with colorectal cancer (CRC) frequently develop liver metastases during the course of their disease. A substantial proportion of them receive neoadjuvant FOLFOX (5-Fluorouracil, Oxaliplatin, Leucovorin) prior to surgery in an attempt to enable successful surgical removal of their metastases and to reduce the risk of recurrence. Yet, the majority of patients progress during treatment or...

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Literature Corpus work: 6a4fd4df-d119-5ec6-b502-630d8ee0d20a
DOI: 10.1101/2021.02.04.429849

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