Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Three-dimensionally Specific Inhibition of DNA Repair-Related Genes by Activated KRAS in Colon Crypt Model

1 May 2010

Abstract excerpt

Growth and differentiation of colonic epithelium are regulated in the three-dimensional (3D) physiological architecture, colonic crypt, and deregulation of 3D interactions is involved in tumorigenesis. Cell-based 3D culture systems provide a suitable approach bridging the gap between two-dimensional (2D) culture and animal models. KRAS mutations are found at high frequencies in human colorectal cancer (CRC);...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3D Printing in Biomedical Research
Share to Cancer Cells and Metastasis
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20454511
DOI: 10.1593/neo.10170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Three-dimensionally Specific Inhibition of DNA Repair-Related Genes by Activated KRAS in Colon Crypt ModelPMID 20454511Read ↗

Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt modelSemantic proximity Read ↗

Origin, development and therapy of colorectal cancer from the perspective of a biologist and an oncologistSemantic proximity Read ↗

2D- and 3D-Based Intestinal Stem Cell Cultures for Personalized MedicineSemantic proximity Read ↗

Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors.Semantic proximity Read ↗

Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS.Semantic proximity Read ↗

Colorectal cancer on a dish: exploring the 3D-sphere culture of primary colorectal cancer cells from an Indonesian perspectiveSemantic proximity Read ↗

Generation of Patient-Derived Colorectal Cancer Organoids for RAS Studies.Semantic proximity Read ↗

Comparative analysis between 2D and 3D colorectal cancer culture models for insights into cellular morphological and transcriptomic variationsSemantic proximity Read ↗

Aspirin-mediated DKK-1 increase rescues Wnt-driven stem-like phenotype in human intestinal organoidsSemantic proximity Read ↗

Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors.Semantic proximity Read ↗

Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosisSemantic proximity Read ↗

Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.