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Pharmacological or genetic inhibition of <i>Scn9a</i> protects beta-cells while reducing insulin secretion in type 1 diabetes

2023-06-12

Abstract excerpt

Pancreatic β-cells are critical for systemic glucose homeostasis, and most of them undergo cell death during the pathogenesis of type 1 diabetes. We previously showed that a Na + channel inhibitor, carbamazepine, could protect β-cells in vitro and in vivo . Here, we confirmed the effects of carbamazepine and other Na + channel inhibitors on human islets and focused on the specific role of the Na + channel gen...

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Identifiers and source

Literature Corpus work
2febab0f-2b82-5a3a-89fa-6b13f119d6ca
DOI
10.1101/2023.06.11.544521
Open publication

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Pharmacological or genetic inhibition of <i>Scn9a</i> protects beta-cells while reducing insulin secretion in type 1 diabetesDOI 10.1101/2023.06.11.544521
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