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Article

Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes.

Diabetes - 1 Jul 2012

Okamoto Koji, Iwasaki Naoko, Doi Kent, Noiri Eisei, Iwamoto Yasuhiko, Uchigata Yasuko, Fujita Toshiro, Tokunaga Katsushi

Abstract excerpt

Potassium inwardly rectifying channel, subfamily J, member 15 (KCNJ15) is a type 2 diabetes-associated risk gene, and Kcnj15 overexpression suppresses insulin secretion in rat insulinoma (INS1) cells. The aim of the current study was to characterize the role of Kcnj15 by knockdown of this gene in vitro and in vivo. Human islet cells were used to determine the expression of KCNJ15. Expression of KCNJ15 mRNA in...

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Source

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Identifiers

PMID: 22566534
DOI: 10.2337/db11-1201
PMCID: PMC3379671

Genes

KCNJ15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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