Article

Molecular Correlates of Glycine Receptor Activity in Human β Cells

2024-12-02

Abstract excerpt

<h4>Objectives</h4> Glycine acts in an autocrine positive feedback loop in human β cells through its ionotropic receptors (GlyRs). In type 2 diabetes (T2D), islet GlyR activity is impaired by unknown mechanisms. We sought to investigate if the GlyR dysfunction in T2D is replicated by hyperglycemia per se , and to further characterize its action in β cells and islets. <h4>Methods</h4> GlyR-mediated currents wer...

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Literature Corpus work: 865c50f5-633c-5b37-a56f-2dd83f46fe4d
DOI: 10.1101/2024.12.02.626463

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