Article

Differential effects of voclosporin and tacrolimus on insulin secretion from human islets

2020-05-04

Abstract excerpt

<h4>Context</h4> The incidence of new onset diabetes after transplant (NODAT) has increased over the past decade, likely due to calcineurin inhibitor-based immunosuppressants, including tacrolimus (TAC) and cyclosporin (CsA). Voclosporin (VCS), a next generation calcineurin inhibitor is reported to cause fewer incidences of NODAT but the reason is unclear. <h4>Objective</h4> Whilst calcineurin signaling plays im...

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Literature Corpus work: 6969b712-3cae-50be-a322-4f0437816a89
DOI: 10.1101/2020.04.30.071324

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