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Article

Loss of α2δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes.

Diabetes - 1 Apr 2017

Mastrolia Vincenzo, Flucher Sylvia M, Obermair Gerald J, Drach Mathias, Hofer Helene, Renström Erik, Schwartz Arnold, Striessnig Jörg, Flucher Bernhard E, Tuluc Petronel

Abstract excerpt

Reduced pancreatic β-cell function or mass is the critical problem in developing diabetes. Insulin release from β-cells depends on Ca2+ influx through high voltage-gated Ca2+ channels (HVCCs). Ca2+ influx also regulates insulin synthesis and insulin granule priming and contributes to β-cell electrical activity. The HVCCs are multisubunit protein complexes composed of a pore-forming α1 and auxiliary β and α2δ...

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Identifiers

PMID: 28115397
DOI: 10.2337/db16-0336
PMCID: PMC7360433

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