Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity.

Cells - 7 Jan 2021

Lockridge Amber, Gustafson Eric, Wong Alicia, Miller Robert F, Alejandro Emilyn U

Abstract excerpt

Insulin-secreting pancreatic β-cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive β-cell target, N-methyl D-aspartate receptors (NMDARs), is unclear. We used multiple models to evaluate glucose homeostasis and insulin secretion in mice with a systemic increase in D-serine (intraperitoneal injection or DAAO mutants without D-serine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Glucose Intolerance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Secreting Cells

Share to Insulin Secretion

Share to N-Methylaspartate

Share to Receptors, N-Methyl-D-Aspartate

Share to Serine

Share to Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 33430405
DOI: 10.3390/cells10010093
PMCID: PMC7826616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity.PMID 33430405Read ↗

D-Serine agonism of GluN1-GluN3 NMDA receptors regulates the activity of enteric neurons and coordinates gut motilitySemantic proximity Read ↗

Molecular Correlates of Glycine Receptor Activity in Human β CellsSemantic proximity Read ↗

Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of <i>GCK</i> -MODYSemantic proximity Read ↗

Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion.Semantic proximity Read ↗

Hepatic serine and lipid metabolism drive diabetic peripheral neuropathySemantic proximity Read ↗

Separately inherited defects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes.Semantic proximity Read ↗

A selective nonpeptide somatostatin receptor 5 agonist effectively decreases insulin secretion in hyperinsulinism.Semantic proximity Read ↗

ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes.Semantic proximity Read ↗

Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations.Semantic proximity Read ↗

Lysine Potentiates Insulin Secretion via AASS-Dependent Catabolism and Regulation of GABA Content and SignalingSemantic proximity Read ↗

Insulin resistance-driven beta-cell adaptation in mice: Mechanistic characterization and 3D analysisSemantic proximity Read ↗

Leucine suppresses glucagon secretion from pancreatic islets by directly modulating α-cell cAMPSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.