Article

Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria to nucleus signaling

2026-04-25

Abstract excerpt

<h4> Abstract </h4> Parkinson’s disease (PD) is commonly associated with dysfunctional mitochondrial homeostasis. PINK1, a S/T kinase mutated in early-onset PD, generates phosphoserine 65 ubiquitin (pS65Ub) on damaged mitochondria facilitating their removal. Here, we show that pS65Ub translocates into the nucleus after generation at damaged mitochondria and is directly attached to substrates by resident E3 ligas...

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Literature Corpus work: 2fe99be3-3e9e-511a-ad1d-d9105f52e84b
DOI: 10.64898/2026.04.24.719390

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