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Article

Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain

4 May 2021

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dysregulation and specifically altered histone acetylation. Nevertheless, and despite the emerging role of epigenetics in age-related brain disorders, the question of whether aberrant histone...

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PMID: 33947435
DOI: 10.1186/s13024-021-00450-7

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