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Article

DAXX in cancer: phenomena, processes, mechanisms and regulation

13 Jul 2019

Abstract excerpt

DAXX displays complex biological functions. Remarkably, DAXX overexpression is a common feature in diverse cancers, which correlates with tumorigenesis, disease progression and treatment resistance. Structurally, DAXX is modular with an N-terminal helical bundle, a docking site for many DAXX interactors (e.g. p53 and ATRX). DAXX's central region folds with the H3.3/H4 dimer, providing a H3.3-specific chaperoning...

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PMID: 31350900
DOI: 10.1093/nar/gkz634

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