Article
Mitochondrial dysfunction-induced H3K27 hyperacetylation perturbs enhancers in Parkinson's disease.
JCI insight - 8 Sept 2021
Huang Minhong, Lou Dan, Charli Adhithiya, Kong Dehui, Jin Huajun, Zenitsky Gary, Anantharam Vellareddy, Kanthasamy Arthi, Wang Zhibin, Kanthasamy Anumantha G
Abstract excerpt
Mitochondrial dysfunction is a major pathophysiological contributor to the progression of Parkinson's disease (PD); however, whether it contributes to epigenetic dysregulation remains unknown. Here, we show that both chemically and genetically driven mitochondrial dysfunctions share a common mechanism of epigenetic dysregulation. Under both scenarios, lysine 27 acetylation of likely variant H3.3 (H3.3K27ac)...
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