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MICAL2 acts through Arp3B isoform-specific Arp2/3 complexes to destabilize branched actin networks

2020-09-21

Abstract excerpt

The Arp2/3 complex (Arp2, Arp3 and ARPC1-5) is essential to generate branched actin filament networks for many cellular processes. Human Arp3, ARPC1 and ARPC5 exist as two isoforms but the functional properties of Arp2/3 iso-complexes is largely unexplored. Here we show that Arp3B, but not Arp3 is subject to regulation by the methionine monooxygenase MICAL2, which is recruited to branched actin networks by coronin...

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Identifiers and source

Literature Corpus work
2fd2515c-6aa1-5127-9286-8b14148f0be3
DOI
10.1101/2020.09.21.306522
Open publication

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MICAL2 acts through Arp3B isoform-specific Arp2/3 complexes to destabilize branched actin networksDOI 10.1101/2020.09.21.306522
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