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Article

Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin.

The Journal of cell biology - 23 Dec 2002

Humphries Christine L, Balcer Heath I, D'Agostino Jessica L, Winsor Barbara, Drubin David G, Barnes Georjana, Andrews Brenda J, Goode Bruce L

Abstract excerpt

Mechanisms for activating the actin-related protein 2/3 (Arp2/3) complex have been the focus of many recent studies. Here, we identify a novel mode of Arp2/3 complex regulation mediated by the highly conserved actin binding protein coronin. Yeast coronin (Crn1) physically associates with the Arp2/3 complex and inhibits WA- and Abp1-activated actin nucleation in vitro. The inhibition occurs specifically in the...

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Identifiers

PMID: 12499356
DOI: 10.1083/jcb.200206113
PMCID: PMC2173993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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