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Article

The Arp2/3 Regulatory System and Its Deregulation in Cancer

6 Dec 2017

Abstract excerpt

The Arp2/3 complex is an evolutionary conserved molecular machine that generates branched actin networks. When activated, the Arp2/3 complex contributes the actin branched junction and thus cross-links the polymerizing actin filaments in a network that exerts a pushing force. The different activators initiate branched actin networks at the cytosolic surface of different cellular membranes to promote their...

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PMID: 29212790
DOI: 10.1152/physrev.00006.2017

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