Article

Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence

2022-01-24

Abstract excerpt

The Arp2/3 complex is a ubiquitous actin nucleator with well-characterized activities in cell organization and movement, but its roles in chromatin-associated and cell cycle-related processes are relatively understudied. We investigated how the Arp2/3 complex affects genomic integrity, mitosis, and cell proliferation using mouse fibroblasts containing an inducible knockout (iKO) of the ArpC2 subunit. We show that...

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Literature Corpus work: b4216af2-fdf4-5c4a-b1af-10dee1e28d53
DOI: 10.1101/2022.01.24.477450

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