Article

Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15

2023-09-28

Abstract excerpt

The class III phosphatidylinositol (PI) 3-kinase complexes I and II (PI3KC3-C1 and -C2) are central to the initiation of macroautophagy and endosomal maturation, respectively. Through three-dimensional classification of a large cryo-EM dataset of human PI3KC3-C1 bound to the small GTPase RAB1A, we were able to map the structural pathway of enzyme activation. The inactive conformation is stabilized by an N -myrist...

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Literature Corpus work: 2fd160c2-fd0b-51a4-bfba-39c9daead96f
DOI: 10.1101/2023.09.28.559894

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