Article

A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution

2025-12-10

Abstract excerpt

RAB5-GTP activation of the multiprotein VPS34 complex II (VPS34-CII) is critical for endosomal sorting and maturation, phagocytosis, and receptor downregulation. RAB5-GTP activates VPS34-CII, by binding to a helical insertion in the C2 domain of VPS34 on the BECLIN1/UVRAG-containing adaptor arm of the complex. The autophagy complex, VPS34 complex I (VPS34-CI), features a unique ATG14L subunit in place of the VPS34...

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Literature Corpus work: 261e4544-ca85-549d-a9ee-f54f3333eba2
DOI: 10.64898/2025.12.08.692904

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