Class III PI3K Vps34: essential roles in autophagy, endocytosis, and heart and liver function

Abstract excerpt

Mammalian phosphatidylinositol (PI) 3-kinases are a family of proteins that share the ability to phosphorylate phosphoinositides at the 3 position of the inositol ring. By doing so, these kinases produce phospholipid molecules that are involved in various cell signaling pathways, such as insulin signaling and endocytosis. The pathways regulated by PI3-kinases are crucial for maintaining cellular homeostasis and...

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