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Article

Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2025

Kovarova Veronika, Bordes Joeri, Mitra Shiladitya, Narayan Sowmya, Springer Margherita, Brix Lea Maria, Deussing Jan M, Schmidt Mathias V

Abstract excerpt

The co-chaperone FKBP51, encoded by FKBP5 gene, is recognized as a psychiatric risk factor for anxiety and depressive disorders due to its crucial role in the stress response. Another key modulator in stress response regulation is the corticotropin releasing hormone (CRH), which is co-expressed with FKBP51 in many stress-relevant brain-regions and cell-types. Together, they intricately influence the balance of...

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Source

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Identifiers

PMID: 39438757
DOI: 10.1038/s41386-024-02008-9
PMCID: PMC11736030

Genes

CRH
FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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