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Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in<i>AR</i>-altered lethal prostate cancer

2023-12-01

Abstract excerpt

<h4>Summary</h4> Metastatic castration-resistant prostate cancer (mCRPC) resistant to androgen receptor (AR)-targeted agents is often lethal. Unfortunately, biomarkers for this deadly disease remain under investigation, and underpinning mechanisms are ill-understood. Here, we applied deep sequencing to ∼100 mCRPC patients prior to the initiation of first-line AR-targeted therapy, which detected AR /enhancer altera...

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Literature Corpus work
2fab459b-9531-57ff-b6f0-c0068a74989e
DOI
10.1101/2023.12.01.23299215
Open publication

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Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in<i>AR</i>-altered lethal prostate cancerDOI 10.1101/2023.12.01.23299215
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