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Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancer

2021-02-10

Abstract excerpt

Prostate cancer is profoundly heterogeneous and patients would benefit from methods that stratify clinically indolent from more aggressive forms of the disease. We employed single-cell assay for transposase-accessible chromatin (ATAC) and RNA sequencing in models of early treatment response and resistance to enzalutamide. In doing so, we identified pre-existing and treatment-persistent cell subpopulations that pos...

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Literature Corpus work
9dcd52cc-18c6-566b-9e4e-12aeb80045f0
DOI
10.1101/2021.02.09.430114
Open publication

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Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancerDOI 10.1101/2021.02.09.430114
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