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Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancer

2021-04-12

Abstract excerpt

<title>Abstract</title> <p>Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. We employed single-cell assays for transposase-accessible chromatin (ATAC) and RNA sequencing in models of early treatment response and resistance to enzalutamide. In doing so, we identified pre-existing and treatment-persistent cell subpopulations...

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Literature Corpus work
a33e8fc7-9f96-5474-a572-db574ed24957
DOI
10.21203/rs.3.rs-384422/v1
Open publication

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Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancerDOI 10.21203/rs.3.rs-384422/v1
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